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KMID : 0616120090400020083
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 2 p.83 ~ p.88
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Inhibitory Activity of Medicinal Plants against Differentiation of Osteoclasts
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Lee Jun-Won
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Abstract
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Bone is continuously remodeled by osteoblasts and osteoclasts. Osteoclasts play an important role in bone metabolism by resorbing the bone matrix. Thus, the compounds inhibiting osteoclasts can improve bone diseases such as osteoporosis. The methanol extracts of 159 herbal medicines were screened for the inhibitory activity against differentiation of osteoclasts. Among the tested extracts, Achuranthis Radix and Corydalis Tuber showed relatively strong inhibitory activity against differentiation of osteoclasts, whereas they have no significant effect on proliferation of osteoclasts.
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KEYWORD
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medicinal plants, osteoclast, osteoporosis, differentiation, Achuranthis Radix, Corydalis Tuber
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